Sulphonylureas and pregnancy

Sulphonylureas and hypoglycaemia.

Toxic effects of four sulphonylureas herbicides on soil microbial biomass.

The effect of four triazinyl-sulfonylurea herbicides (cinosulfuron, prosulfuron, thifensulfuron methyl, triasulfuron) on soil microbial biomass, soil respiration, metabolic activity, metabolic quotient, and some enzymatic activities (acid and alkaline phosphatase, β-glucosidase, arylsulphatase, and fluorescein diacetate hydrolysis) were monitored under controlled conditions over 30 days. The he...

Optimal utilisation of sulphonylureas in resource-constrained settings

Sulphonylureas (SUs) are oral anti-diabetic drugs (OADs) that were introduced more than 60 years ago. Clinicians are familiar with their use and they remain extensively used. However, the SU class is associated with adverse effects of weight gain and hypoglycaemia. In addition, their effects on cardiovascular events remain contentious. Newer classes of anti-diabetic agents have been developed a...

Variation in KCNQ1 is associated with therapeutic response to sulphonylureas

BACKGROUND We aimed to analyse quantitative effects of treatment with sulphonylurea in addition to metformin on parameters of glycemic control in relation to KCNQ1 genotypes, and to identify factors predictive for the response to sulphonylurea treatment. MATERIAL/METHODS Effect of 6-month sulphonylurea therapy in addition to metformin on glycemic control according to KCNQ1 genotypes was evalu...

Cancer and Pregnancy

جای خوشبختی است که بروز سرطان، در زنان حامله، پدیده ای نسبتاً نادر است. زیرا این حالت هم برای پزشک و هم برای بیمار مأیوس کننده می باشد. شاید بتوان گفت در هیچ جای دیگر در علوم پزشکی چنین امر،نامطلوبی وجود ندارد. ارتباط نزدیک بین درمان و مرگ وجود دارد. شیوع سرطان همراه با حاملگی در ۱ در ۱۰۰۰ مورد است که از این میان ۱ در هر ۱ . ۱۸ مورد از آن بدخیمی های همراه با حاملگی است.